El Mehdi Harbili, Jalal Oubenjah, Mahdi Laarabi, Ahmed Rouihi, Mouad Moujoud, Mohamed Zalagh, Saloua Ouraini, Bouchaib Hemmaoui, Fouad Benariba, Noureddine Errami
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 3
Issue: 7
Date of Publication: 2026/07/01
Extramedullary plasmacytoma is a rare plasma cell neoplasm, most frequently involving the upper aerodigestive tract. Endonasal localization is uncommon and may represent either a solitary lesion or the first manifestation of multiple myeloma. Clinical presentation is often nonspecific, which may lead to diagnostic delay. We report the case of an 83-year-old man presenting with chronic nasal obstruction and recurrent epistaxis. Endoscopic examination revealed a friable submucosal mass occupying both nasal cavities with extension to the hard palate. Imaging demonstrated an aggressive locally advanced endonasal lesion with skull base extension. Histopathological and immunohistochemical analysis confirmed a lambda light-chain plasmacytoma. Subsequent hematological investigations established the diagnosis of multiple myeloma. The patient received systemic therapy according to current hematological protocols. This case highlights the importance of considering plasmacytoma in the differential diagnosis of destructive endonasal masses and underscores the need for systematic hematological assessment.
Plasmacytoma; Multiple Myeloma; Nose Neoplasms; Nasal Cavity; Skull Base; Palate, Hard; Immunoglobulin Lambda-Chains; Diagnosis, Differential.
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