Isolated Metachronous Splenic Metastasis Secondary to Gastric Neuroendocrine Carcinoma: Case Report

Authors

Alia Yassine Kassab, Lina Lasri, Mehdi Salmane, Asaad El Bakkari, Hounayda Jerguigue, Youssef Omor, Rachida Latib

Journal Information

Journal: Medpeer Publisher

ISSN: 3066-2737

Volume: 3

Issue: 1

Date of Publication: 2026/01/23

DOI: 10.70780/medpeer.000QGR3

Abstract

We report a rare case of isolated metachronous splenic metastasis from poorly differentiated large-cell gastric neuroendocrine carcinoma, contributing to the scarce literature on atypical metastatic patterns. A 66-year-old woman, asymptomatic during routine surveillance, was found to have a solitary arterial-enhancing splenic nodule on imaging, with normal clinical examination and laboratory tests. Total splenectomy was performed, and histopathology confirmed metastatic large-cell neuroendocrine carcinoma consistent with the gastric primary. The patient recovered uneventfully and resumed routine oncologic follow-up. This case underscores that, although extremely uncommon, isolated splenic metastasis should be considered during follow-up of gastric neuroendocrine carcinoma, and that timely splenectomy can provide both diagnostic confirmation and therapeutic benefit, highlighting the importance of vigilant surveillance and recognition of unusual metastatic sites.

Keywords

Large-cell neuroendocrine carcinoma, spleen metastasis, metachronous metastasis, splenectomy, case report